“There are classes of compounds such as polyphenols found in plant-based food, curcumin (found in turmeric), and resveratrol (found in grapes), have been shown to not only slow down the aging process, but also possess anti-viral properties,” stated Dr. Amjad Husain, Principal Scientist, and CEO of Innovation and Incubation Heart for Entrepreneurship (IICE), IISER Bhopal, in an announcement.
Another polyphenols that the researchers have recognized as being helpful for each Covid-19 therapy and comorbidity situations resembling diabetes and growing old could embrace catechins (current in inexperienced tea, cocoa and berries), procyanidins (present in apples, cinnamon and grape pores and skin), and theaflavin (present in black tea).
The researchers additionally current proof of some current potential anti-aging medicine resembling Rapamycin that may be explored for the Covid-19 therapy due to the widespread biochemical pathways related to these ailments. One other such instance is a drug Metformin , which is often used to regulate blood sugar.
The overview confirmed that on the molecular degree, there are intersecting pathways which are widespread to diabetes, growing old, and Covid-19. All three situations are related to oxidative stress and reducing of the immune response and issues arising from them result in the onset of quite a few different ailments resembling cardiovascular problems, eye ailments, neuropathy (nerve ailments), and nephropathy (kidney issues).
The researchers consider that a really perfect therapeutic candidate for Covid-19 ought to be capable of goal the pathways which are widespread to diabetes, growing old and the SARS-CoV-2 an infection.
Additional, computational research confirmed that lipids current in cell membranes play an vital function in coronavirus infectivity.
Pure compounds resembling polyphenols could have an effect on the binding of the virus to host receptors and the molecular interactions required for virus replication and launch, thereby stopping the an infection in its early phases, the workforce defined.